1ml=1mg (1:1000 concentration) =1ampoule.

1:1000 concentration (1mg/ml) I/V for emergency resuscitation.

1:10,000 concentrations (100 mcg/ml) for individual doses (If BP and HR are both decreased).

1:100,000 concentrations (10 mcg/ml) for individual dose (If BP is decreased).

Infusion= 0.01-0.3mcg/kg/min.

1:1000 concentration=1ml=1mg (Undiluted).

1:10,000concentration=100 mcg/ml (Drawing up the whole 1ml in 1:1000 adrenaline concentration ampoule and dilute with 9ml 0.9% sodium chloride injection).

1:100,000 concentration=10 mcg/ml (Drawing up the 1ml in 1:10,000 adrenaline concentration from the 1 ^st syringe and dilute with 9ml 0.9% sodium chloride injection).

4 mg Adrenaline (4ml) and 46 ml NS /D5=50ml (via syringe pump).

Dose chart can be used which gives mL/hr based on body weight (as shown below).

Weight in KG

Adrenaline dose mcg/kg/min

0.01

0.02

0.05

0.1

0.15

0.2

0.3

30

0.25

0.5

1.2

2.5

3.8

5

7.5

40

0.3

0.6

1.5

3

4.5

6

9

50

0.4

0.8

2

4

6

8

12

60

0.5

1

2.5

5

7.5

10

15

70

0.55

1.1

2.8

5.5

8

11

16

80

0.6

1.2

3

6

9

12

18

90

0.7

1.4

3.5

7

10.5

14

21

100

0.8

1.6

4

8

12

16

24

1ml=0.6mg=1 Ampoule.

Maximum dose: 3 mg.

1amp=150mg (3ml).

Loading dose= 150 mg (3ml) in 100ml 5% Dextrose over 10 minutes.

Loading dose can be repeated once if needed.

Total 900 mg over 24hour for maintenance dose.

Preparation (1ml=3 mg)

Dose

● 6 mg dose followed by a 20 ml NS flush for rapid infusion using 3-way stopcock [due to its short half-life], Second dose of 12 mg using the same procedure and third dose of 12-18 mg using the same procedure. (via peripheral line).

● Initial dose should be reduced to 3 mg with subsequent doses of 6mg, then 9 mg if needed. (via central line).

2% lidocaine= 20 mg/ml.

1-1.5 mg/kg slow IV bolus over 2-3 minutes (Undiluted).

May repeat doses of 0.5-0.75 mg/kg in 5-10 minutes up to 3 mg/kg total if refractory Ventricular Fibrillation or pulseless Ventricular Tachycardia.

Continuous infusion: 1-4 mg/min IV after return of perfusion

Administer 0.5 mg/kg bolus and reassess infusion if arrhythmia reappears during constant infusion

1ml (2mg) Isoprenaline + 49ml 5% dextrose= 50 ml (which is equivalent to 40 mcg per ml).

Infusion rate = 1-10 mcg/min.

Consider titrating up in steps of 1microgram/min at intervals of 2-3 minutes.

Do NOT use Sodium Chloride 0.9% as diluent.

1 ampoule of 7.5% sodium bicarbonate =10 ml=8.92 mEq (rounded to 10 for practical purposes).

Metabolic acidosis; Consider bicarbonate therapy in patients with either a pH of <7.1 or in patients with severe acute kidney injury and a pH of ≤7.2.

Intermittent therapy

● 89.2 mEq (100 ml of 7.5% sodium bicarbonate) once over 1 to 2 minutes; reassess pH, serum bicarbonate level, and clinical status every 2 hours.

● If pH remains below target, administer an additional 44.6 to 89.2 mEq (50 to 100 ml) sodium bicarbonate or initiate a continuous infusion.

Infusion therapy

● Calculate the bicarbonate deficit formula.

● Sodium bicarbonate estimated dose (mEq) = 0.5 × weight (kg) × [goal serum bicarbonate – observed serum bicarbonate (mEq/L)]

● Administer the calculated amount of bicarbonate (mEq) over 2 to 4 hours and reassess pH, serum bicarbonate level, and clinical status every 2 hours, and adjust dose as needed until goals are reached. Example; 0.5×50(kg) × [24-18] = 150 mEq (which is 75 ml/hour)

Hyperkalemia with cardiac arrest: Intermittent bolus: IV: 50 mEq over 5 minutes.

Hyperkalemia with metabolic acidosis:150 mEq in 1 L of D5W over 2 to 4 hours.

Dose :5 - 20 mcg/kg/min.

Use in dosage: 5/7.5/10/15/20 mcg/kg/min.

Route: Peripheral/ Central line (Most Distal Port).

Preparation:

Body weight x 3 in 50 ml in NS/D5W

Body weight x 6 in 100 ml NS/D5W Then, ml/hr. = mcg/kg/min; e.g., 5 ml/hr = 5 mcg/kg/min

0.01- 0.3 mcg/kg/min

Route: Central line (Most Distal Port)

Dose chart can be used which gives ml/hr based on body weight (as shown below).

Adjust the weight to the nearest number.

Preparation: 4mg (Two ampoules) in 50 ml NS/D5W (4ml noradrenaline and 46ml

NS/D5W).

Weight in KG

Noradrenaline dose (mcg/kg/min)

0.01

0.02

0.05

0.1

0.15

0.2

0.3

30

0.25

0.5

1.2

2.5

3.8

5

7.5

40

0.3

0.6

1.5

3

4.5

6

9

50

0.4

0.8

2

4

6

8

12

60

0.5

1

2.5

5

7.5

10

15

70

0.55

1.1

2.8

5.5

8

11

16

80

0.6

1.2

3

6

9

12

18

90

0.7

1.4

3.5

7

10.5

14

21

100

0.8

1.6

4

8

12

16

24

50 to 100 mcg every 1-2 min for resuscitation of shock management of hypotension as Rescue drug (during procedural sedations, transfer, etc.)

Route: Central line (Most Distal Port) or Peripheral Line.

Drawing up the 1ml/10mg concentration of phenylephrine and dilute with 100ml 0.9% sodium chloride. So, 1ml=100mcg.

Infusion: 0.5 - 5 mcg/ kg/ min